Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies

Jodie Ouahed; Elizabeth Spencer; Daniel Kotlarz; Dror S Shouval; Matthew Kowalik; Kaiyue Peng; Michael Field; Leslie Grushkin-Lerner; Sung-Yun Pai; Athos Bousvaros; Judy Cho; Carmen Argmann; Eric Schadt; Dermot P B Mcgovern; Michal Mokry; Edward Nieuwenhuis; Hans Clevers; Fiona Powrie; Holm Uhlig; Christoph Klein; Aleixo Muise; Marla Dubinsky; Scott B Snapper

doi:10.1093/ibd/izz259

Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies

Jodie Ouahed, Elizabeth Spencer, Daniel Kotlarz, Dror S Shouval, Matthew Kowalik, Kaiyue Peng, Michael Field, Leslie Grushkin-Lerner, Sung-Yun Pai, Athos Bousvaros, Judy Cho, Carmen Argmann, Eric Schadt, Dermot P B Mcgovern, Michal Mokry, Edward Nieuwenhuis, Hans Clevers, Fiona Powrie, Holm Uhlig, Christoph KleinAleixo Muise, Marla Dubinsky, Scott B Snapper

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

120 Citaten (Scopus)

Samenvatting

Very early onset inflammatory bowel disease (VEO-IBD) is defined as IBD presenting before 6 years of age. When compared with IBD diagnosed in older children, VEO-IBD has some distinct characteristics such as a higher likelihood of an underlying monogenic etiology or primary immune deficiency. In addition, patients with VEO-IBD have a higher incidence of inflammatory bowel disease unclassified (IBD-U) as compared with older-onset IBD. In some populations, VEO-IBD represents the age group with the fastest growing incidence of IBD. There are contradicting reports on whether VEO-IBD is more resistant to conventional medical interventions. There is a strong need for ongoing research in the field of VEO-IBD to provide optimized management of these complex patients. Here, we provide an approach to diagnosis and management of patients with VEO-IBD. These recommendations are based on expert opinion from members of the VEO-IBD Consortium (www.VEOIBD.org). We highlight the importance of monogenic etiologies, underlying immune deficiencies, and provide a comprehensive description of monogenic etiologies identified to date that are responsible for VEO-IBD.

Originele taal-2	Engels
Tijdschrift	Inflammatory Bowel Diseases
DOI's	https://doi.org/10.1093/ibd/izz259
Status	E-pub ahead of print - 03 dec. 2019

Toegang tot document

10.1093/ibd/izz259

Citeer dit

Ouahed, J., Spencer, E., Kotlarz, D., Shouval, D. S., Kowalik, M., Peng, K., Field, M., Grushkin-Lerner, L., Pai, S.-Y., Bousvaros, A., Cho, J., Argmann, C., Schadt, E., Mcgovern, D. P. B., Mokry, M., Nieuwenhuis, E., Clevers, H., Powrie, F., Uhlig, H., ... Snapper, S. B. (2019). Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies. Inflammatory Bowel Diseases. Online publicatie vooraf. https://doi.org/10.1093/ibd/izz259

@article{ab5c54ea8f2144ba86d5242e51a3e42f,

title = "Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies",

abstract = "Very early onset inflammatory bowel disease (VEO-IBD) is defined as IBD presenting before 6 years of age. When compared with IBD diagnosed in older children, VEO-IBD has some distinct characteristics such as a higher likelihood of an underlying monogenic etiology or primary immune deficiency. In addition, patients with VEO-IBD have a higher incidence of inflammatory bowel disease unclassified (IBD-U) as compared with older-onset IBD. In some populations, VEO-IBD represents the age group with the fastest growing incidence of IBD. There are contradicting reports on whether VEO-IBD is more resistant to conventional medical interventions. There is a strong need for ongoing research in the field of VEO-IBD to provide optimized management of these complex patients. Here, we provide an approach to diagnosis and management of patients with VEO-IBD. These recommendations are based on expert opinion from members of the VEO-IBD Consortium (www.VEOIBD.org). We highlight the importance of monogenic etiologies, underlying immune deficiencies, and provide a comprehensive description of monogenic etiologies identified to date that are responsible for VEO-IBD.",

author = "Jodie Ouahed and Elizabeth Spencer and Daniel Kotlarz and Shouval, {Dror S} and Matthew Kowalik and Kaiyue Peng and Michael Field and Leslie Grushkin-Lerner and Sung-Yun Pai and Athos Bousvaros and Judy Cho and Carmen Argmann and Eric Schadt and Mcgovern, {Dermot P B} and Michal Mokry and Edward Nieuwenhuis and Hans Clevers and Fiona Powrie and Holm Uhlig and Christoph Klein and Aleixo Muise and Marla Dubinsky and Snapper, {Scott B}",

year = "2019",

month = dec,

day = "3",

doi = "10.1093/ibd/izz259",

language = "English",

journal = "Inflammatory Bowel Diseases",

issn = "1078-0998",

publisher = "Oxford University Press",

}

Ouahed, J, Spencer, E, Kotlarz, D, Shouval, DS, Kowalik, M, Peng, K, Field, M, Grushkin-Lerner, L, Pai, S-Y, Bousvaros, A, Cho, J, Argmann, C, Schadt, E, Mcgovern, DPB, Mokry, M, Nieuwenhuis, E, Clevers, H, Powrie, F, Uhlig, H, Klein, C, Muise, A, Dubinsky, M & Snapper, SB 2019, 'Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies', Inflammatory Bowel Diseases. https://doi.org/10.1093/ibd/izz259

TY - JOUR

T1 - Very Early Onset Inflammatory Bowel Disease

T2 - A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies

AU - Ouahed, Jodie

AU - Spencer, Elizabeth

AU - Kotlarz, Daniel

AU - Shouval, Dror S

AU - Kowalik, Matthew

AU - Peng, Kaiyue

AU - Field, Michael

AU - Grushkin-Lerner, Leslie

AU - Pai, Sung-Yun

AU - Bousvaros, Athos

AU - Cho, Judy

AU - Argmann, Carmen

AU - Schadt, Eric

AU - Mcgovern, Dermot P B

AU - Mokry, Michal

AU - Nieuwenhuis, Edward

AU - Clevers, Hans

AU - Powrie, Fiona

AU - Uhlig, Holm

AU - Klein, Christoph

AU - Muise, Aleixo

AU - Dubinsky, Marla

AU - Snapper, Scott B

PY - 2019/12/3

Y1 - 2019/12/3

N2 - Very early onset inflammatory bowel disease (VEO-IBD) is defined as IBD presenting before 6 years of age. When compared with IBD diagnosed in older children, VEO-IBD has some distinct characteristics such as a higher likelihood of an underlying monogenic etiology or primary immune deficiency. In addition, patients with VEO-IBD have a higher incidence of inflammatory bowel disease unclassified (IBD-U) as compared with older-onset IBD. In some populations, VEO-IBD represents the age group with the fastest growing incidence of IBD. There are contradicting reports on whether VEO-IBD is more resistant to conventional medical interventions. There is a strong need for ongoing research in the field of VEO-IBD to provide optimized management of these complex patients. Here, we provide an approach to diagnosis and management of patients with VEO-IBD. These recommendations are based on expert opinion from members of the VEO-IBD Consortium (www.VEOIBD.org). We highlight the importance of monogenic etiologies, underlying immune deficiencies, and provide a comprehensive description of monogenic etiologies identified to date that are responsible for VEO-IBD.

AB - Very early onset inflammatory bowel disease (VEO-IBD) is defined as IBD presenting before 6 years of age. When compared with IBD diagnosed in older children, VEO-IBD has some distinct characteristics such as a higher likelihood of an underlying monogenic etiology or primary immune deficiency. In addition, patients with VEO-IBD have a higher incidence of inflammatory bowel disease unclassified (IBD-U) as compared with older-onset IBD. In some populations, VEO-IBD represents the age group with the fastest growing incidence of IBD. There are contradicting reports on whether VEO-IBD is more resistant to conventional medical interventions. There is a strong need for ongoing research in the field of VEO-IBD to provide optimized management of these complex patients. Here, we provide an approach to diagnosis and management of patients with VEO-IBD. These recommendations are based on expert opinion from members of the VEO-IBD Consortium (www.VEOIBD.org). We highlight the importance of monogenic etiologies, underlying immune deficiencies, and provide a comprehensive description of monogenic etiologies identified to date that are responsible for VEO-IBD.

U2 - 10.1093/ibd/izz259

DO - 10.1093/ibd/izz259

M3 - Article

C2 - 31833544

SN - 1078-0998

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

ER -

Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit