Whole brain measurements of the positive BOLD response variability during a finger tapping task at 7 T show regional differences in its profiles

TY - JOUR

T1 - Whole brain measurements of the positive BOLD response variability during a finger tapping task at 7 T show regional differences in its profiles

AU - Boillat, Yohan

AU - van der Zwaag, Wietske

N1 - © 2018 International Society for Magnetic Resonance in Medicine.

PY - 2019

Y1 - 2019

N2 - PURPOSE: The positive BOLD response can vary across brain regions. Here, the positive BOLD responses of motor regions, including the cerebellum, were investigated by fast fMRI acquisition.METHODS: The participants were asked to perform an event-related finger-tapping task in a 7T MRI scanner during a fast 3D-EPI controlled aliasing in parallel imaging acquisition protocol (CAIPI; TR = 399 ms). The positive BOLD responses of 6 motor regions were extracted and their timings and shapes measured.RESULTS: Compared with other brain regions, the positive BOLD responses in the cerebellum and secondary somatosensory cortex showed delayed onsets, but no differences were observed for the time to-peak. Additionally, variations of the undershoot and main peak amplitudes were also observed, and undershoot was quasi-absent in the cerebellum.CONCLUSION: This study confirms that care should be taken when drawing conclusions about neuronal activity from the BOLD signal, particularly for the cerebellum.

AB - PURPOSE: The positive BOLD response can vary across brain regions. Here, the positive BOLD responses of motor regions, including the cerebellum, were investigated by fast fMRI acquisition.METHODS: The participants were asked to perform an event-related finger-tapping task in a 7T MRI scanner during a fast 3D-EPI controlled aliasing in parallel imaging acquisition protocol (CAIPI; TR = 399 ms). The positive BOLD responses of 6 motor regions were extracted and their timings and shapes measured.RESULTS: Compared with other brain regions, the positive BOLD responses in the cerebellum and secondary somatosensory cortex showed delayed onsets, but no differences were observed for the time to-peak. Additionally, variations of the undershoot and main peak amplitudes were also observed, and undershoot was quasi-absent in the cerebellum.CONCLUSION: This study confirms that care should be taken when drawing conclusions about neuronal activity from the BOLD signal, particularly for the cerebellum.

U2 - 10.1002/mrm.27566

DO - 10.1002/mrm.27566

M3 - Article

C2 - 30368894

SN - 0740-3194

VL - 81

SP - 2720

EP - 2727

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

ER -