Wnt signaling in the intestinal epithelium: from endoderm to cancer.

TY - JOUR

T1 - Wnt signaling in the intestinal epithelium: from endoderm to cancer.

AU - Gregorieff, A.

AU - Clevers, J.C.

N1 - doi: 10.1101/gad.1295405

PY - 2005

Y1 - 2005

N2 - The Wnt pathway controls cell fate during embryonic development. It also persists as a key regulator of homeostasis in adult self-renewing tissues. In these tissues, mutational deregulation of the Wnt cascade is closely associated with malignant transformation. The intestinal epithelium represents the best-understood example for the closely linked roles of Wnt signaling in homeostatic self-renewal and malignant transformation. In this review, we outline current understanding of the physiological role of Wnt signaling in intestinal biology. From this perspective, we then describe how mutational subversion of the Wnt cascade leads to colorectal cancer.

AB - The Wnt pathway controls cell fate during embryonic development. It also persists as a key regulator of homeostasis in adult self-renewing tissues. In these tissues, mutational deregulation of the Wnt cascade is closely associated with malignant transformation. The intestinal epithelium represents the best-understood example for the closely linked roles of Wnt signaling in homeostatic self-renewal and malignant transformation. In this review, we outline current understanding of the physiological role of Wnt signaling in intestinal biology. From this perspective, we then describe how mutational subversion of the Wnt cascade leads to colorectal cancer.

M3 - Article

VL - 19

SP - 877

EP - 890

JO - Genes and Development

JF - Genes and Development

SN - 0890-9369

ER -