Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2

M.C. Verhoeven; C. Haase; V.M. Christoffels; G. Weidinger; J. Bakkers

doi:10.1002/bdra.20804

Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2

M.C. Verhoeven, C. Haase, V.M. Christoffels, G. Weidinger, J. Bakkers

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

62 Citaten (Scopus)

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In the developing heart, the atrioventricular canal (AVC) is essential for separation and alignment of the cardiac chambers, for valve formation, and serves to delay the electrical impulse from the atria to the ventricles. Defects in various aspects of its formation are the most common form of congenital heart defects. Using mutant and transgenic approaches in zebrafish, this study demonstrates that Wnt/beta-catenin signaling is both sufficient and required for the induction of BMP4 and Tbx2b expression in the AVC and consequently the proper patterning of the myocardium. Furthermore, genetic analysis shows that Wnt/beta-catenin signaling is upstream and in a linear pathway with BMP and Tbx2 during AVC specification.

Originele taal-2	Engels
Pagina's (van-tot)	435-440
Tijdschrift	Birth Defects Research Part A: Clinical and Molecular Teratology
Volume	91
Nummer van het tijdschrift	6
DOI's	https://doi.org/10.1002/bdra.20804
Status	Gepubliceerd - 2011

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abstract = "In the developing heart, the atrioventricular canal (AVC) is essential for separation and alignment of the cardiac chambers, for valve formation, and serves to delay the electrical impulse from the atria to the ventricles. Defects in various aspects of its formation are the most common form of congenital heart defects. Using mutant and transgenic approaches in zebrafish, this study demonstrates that Wnt/beta-catenin signaling is both sufficient and required for the induction of BMP4 and Tbx2b expression in the AVC and consequently the proper patterning of the myocardium. Furthermore, genetic analysis shows that Wnt/beta-catenin signaling is upstream and in a linear pathway with BMP and Tbx2 during AVC specification.",

author = "M.C. Verhoeven and C. Haase and V.M. Christoffels and G. Weidinger and J. Bakkers",

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Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2. / Verhoeven, M.C.; Haase, C.; Christoffels, V.M. et al.
In: Birth Defects Research Part A: Clinical and Molecular Teratology, Vol. 91, Nr. 6, 2011, blz. 435-440.

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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AU - Verhoeven, M.C.

AU - Haase, C.

AU - Christoffels, V.M.

AU - Weidinger, G.

AU - Bakkers, J.

N1 - Reporting year: 2011

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AB - In the developing heart, the atrioventricular canal (AVC) is essential for separation and alignment of the cardiac chambers, for valve formation, and serves to delay the electrical impulse from the atria to the ventricles. Defects in various aspects of its formation are the most common form of congenital heart defects. Using mutant and transgenic approaches in zebrafish, this study demonstrates that Wnt/beta-catenin signaling is both sufficient and required for the induction of BMP4 and Tbx2b expression in the AVC and consequently the proper patterning of the myocardium. Furthermore, genetic analysis shows that Wnt/beta-catenin signaling is upstream and in a linear pathway with BMP and Tbx2 during AVC specification.

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DO - 10.1002/bdra.20804

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JF - Birth Defects Research Part A: Clinical and Molecular Teratology

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ER -

Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2

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