Wnt/beta-catenin signaling and disease

TY - JOUR

T1 - Wnt/beta-catenin signaling and disease

AU - Clevers, H.

AU - Nusse, R.

N1 - Reporting year: 2012

PY - 2012

Y1 - 2012

N2 - The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/beta-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

AB - The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/beta-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

U2 - 10.1016/j.cell.2012.05.012

DO - 10.1016/j.cell.2012.05.012

M3 - Article

SN - 0092-8674

VL - 149

SP - 1192

EP - 1205

JO - Cell

JF - Cell

IS - 6

ER -