Wnt/beta-catenin signaling in development and disease.

TY - JOUR

T1 - Wnt/beta-catenin signaling in development and disease.

AU - Clevers, J.C.

N1 - doi: 10.1016/j.cell.2006.10.018

PY - 2006

Y1 - 2006

N2 - A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.

AB - A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.

M3 - Article

SN - 0092-8674

VL - 127

SP - 469

EP - 480

JO - Cell

JF - Cell

ER -