Zebrafish provides a novel model for lymphatic vascular research

T. Karpanen; S. Schulte-Merker

doi:10.1016/B978-0-12-381320-6.00009-6

Zebrafish provides a novel model for lymphatic vascular research

T. Karpanen, S. Schulte-Merker

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

16 Citaten (Scopus)

Samenvatting

The mammalian lymphatic vasculature has an important function in the maintenance of tissue fluid homeostasis, absorption of dietary lipids, and immune surveillance. The lymphatic vessels are also recruited by many tumors as primary routes for metastasis and mediate immune responses in inflammatory diseases, whereas dysfunction of the lymphatic drainage leads to lymphedema. The characterization of a lymphatic vasculature in zebrafish has made the advantages of this small model organism, the suitability for intravital time-lapse imaging of developmental processes and the amenability for chemical and forward genetic screens, available to lymphatic vascular research. Here we review our current understanding of embryonic lymphangiogenesis in zebrafish, its molecular and anatomical similarities to mammalian lymphatic vascular development, and the possibilities zebrafish offers to complement mouse models and cell culture assays in the lymphangiogenesis field.

Originele taal-2	Engels
Pagina's (van-tot)	223-238
Tijdschrift	Methods in Cell Biology
Volume	105
DOI's	https://doi.org/10.1016/B978-0-12-381320-6.00009-6
Status	Gepubliceerd - 2011

Toegang tot document

10.1016/B978-0-12-381320-6.00009-6

Citeer dit

@article{6019bf751c764d45b11b374d65bc5696,

title = "Zebrafish provides a novel model for lymphatic vascular research",

abstract = "The mammalian lymphatic vasculature has an important function in the maintenance of tissue fluid homeostasis, absorption of dietary lipids, and immune surveillance. The lymphatic vessels are also recruited by many tumors as primary routes for metastasis and mediate immune responses in inflammatory diseases, whereas dysfunction of the lymphatic drainage leads to lymphedema. The characterization of a lymphatic vasculature in zebrafish has made the advantages of this small model organism, the suitability for intravital time-lapse imaging of developmental processes and the amenability for chemical and forward genetic screens, available to lymphatic vascular research. Here we review our current understanding of embryonic lymphangiogenesis in zebrafish, its molecular and anatomical similarities to mammalian lymphatic vascular development, and the possibilities zebrafish offers to complement mouse models and cell culture assays in the lymphangiogenesis field.",

author = "T. Karpanen and S. Schulte-Merker",

note = "Reporting year: 2011",

year = "2011",

doi = "10.1016/B978-0-12-381320-6.00009-6",

language = "English",

volume = "105",

pages = "223--238",

journal = "Methods in Cell Biology",

issn = "0091-679X",

publisher = "Academic Press",

}

TY - JOUR

T1 - Zebrafish provides a novel model for lymphatic vascular research

AU - Karpanen, T.

AU - Schulte-Merker, S.

N1 - Reporting year: 2011

PY - 2011

Y1 - 2011

N2 - The mammalian lymphatic vasculature has an important function in the maintenance of tissue fluid homeostasis, absorption of dietary lipids, and immune surveillance. The lymphatic vessels are also recruited by many tumors as primary routes for metastasis and mediate immune responses in inflammatory diseases, whereas dysfunction of the lymphatic drainage leads to lymphedema. The characterization of a lymphatic vasculature in zebrafish has made the advantages of this small model organism, the suitability for intravital time-lapse imaging of developmental processes and the amenability for chemical and forward genetic screens, available to lymphatic vascular research. Here we review our current understanding of embryonic lymphangiogenesis in zebrafish, its molecular and anatomical similarities to mammalian lymphatic vascular development, and the possibilities zebrafish offers to complement mouse models and cell culture assays in the lymphangiogenesis field.

AB - The mammalian lymphatic vasculature has an important function in the maintenance of tissue fluid homeostasis, absorption of dietary lipids, and immune surveillance. The lymphatic vessels are also recruited by many tumors as primary routes for metastasis and mediate immune responses in inflammatory diseases, whereas dysfunction of the lymphatic drainage leads to lymphedema. The characterization of a lymphatic vasculature in zebrafish has made the advantages of this small model organism, the suitability for intravital time-lapse imaging of developmental processes and the amenability for chemical and forward genetic screens, available to lymphatic vascular research. Here we review our current understanding of embryonic lymphangiogenesis in zebrafish, its molecular and anatomical similarities to mammalian lymphatic vascular development, and the possibilities zebrafish offers to complement mouse models and cell culture assays in the lymphangiogenesis field.

U2 - 10.1016/B978-0-12-381320-6.00009-6

DO - 10.1016/B978-0-12-381320-6.00009-6

M3 - Article

SN - 0091-679X

VL - 105

SP - 223

EP - 238

JO - Methods in Cell Biology

JF - Methods in Cell Biology

ER -

Zebrafish provides a novel model for lymphatic vascular research

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit